مجله دانشگاه علوم پزشکی قم
سال پانزدهم شماره 8 (پیاپی 115، آبان 1400)

Chronic kidney disease and hemodialysis have adverse effects on the patient's physical and mental health.. The aim of this study was to evaluate the effectiveness of commitment-based treatment and acceptance on depression and post-traumatic stress disorder in hemodialysis patients.

The present study was clinical trial with pretest, posttest and follow-up with a control group. Hemodialysis was performed on 36 patients referred to Imam Ali and Shahid Rajaei Hospital in Karaj. Which were available by sampling method and randomly divided into two groups: acceptance and commitment based treatment (n = 18) and control group (n = 18). The research tool was Beck Post Traumatic Growth and Depression Inventory. The intervention group received acceptance and commitment therapy individually in 8 sessions of 90 minutes. Data were analyzed using analysis of covariance in SPSS software.

Acceptance and commitment-based therapy was effective in improving depressive symptoms and increasing post-traumatic growth in dialysis patients (p≤0.001).

Acceptance and commitment therapy can be used as an effective psychological intervention to improve the psychological problems of patients undergoing hemodialysis.

Knowledge is a valuable and strategic resource and knowledge creation is impossible without considering Organizational learning culture. Therefore, this study aimed at investigating the effect of component of learning culture on knowledge creation in public hospitals.

This descriptive-analytical and exploratory study was performed on 570 employees in public hospitals of Qom. Data were collected via a standard researcher-made questionnaire. The validity of the instrument was assessed through content validity, convergent validity. Furthermore, the reliability was assessed by Cronbachchr('39')s alpha and composite reliability. Data were analyzed through exploratory and confirmatory factor analysis and structural equation modeling, using SPSS and Lisrel 8.8 software.

The mean and standard deviation of the components of learning culture and knowledge creation were 3.11 ± 1.35 and 3.42 ± 1.11, respectively. Exploratory factor analysis showed that KMO equaled 0.944 and Bartlett sphericity test was significant at the significance level of 0.001. Cronbachchr('39')s alpha of the two components was 0.972 and 0.974, respectively, while the composite reliability was calculated to be 0.824 and 0.847, respectively. Convergence validity was 0.884 and 0.846, respectively. The exploratory factor analysis categorized the variables in two dimensions of learning culture and knowledge creation. Finally, its fit indicators confirmed the above-mentioned dimensions.

The results showed that learning culture has a positive and significant relationship with the knowledge creation. Therefore, supporting senior managers in holding training workshops on learning culture and knowledge creation in the hospital can be useful for staff in creating knowledge.

The present study aimed to investigate marital satisfaction in women referred to Gynecology Clinic in Jahrom City during the Covid 19 pandemic.

The present study is a cross-sectional descriptive study that was conducted on women in Jahrom City in 2020. Data collection was done by using ENRICH Marital Satisfaction Scale (EMS).

According to the results, the marital satisfaction of most of the subjects was high (49%) and19.1% were very satisfied with their marital status. There was a significant inverse relationship between marital satisfaction with duration of marriage (r = -0.156, p = 0.030). the number of children (r =-0.232,p =0.002) and income levels (F(4,175) = 2.560, p = 0.040).

The results showed that marital satisfaction is high among the women. Besides, the higher the education level, the opportunities for earning money and the economic status the couples benefit from, the more they are satisfied with their marital relationship.

The main treatment for celiac disease is a gluten-free diet. Gluten infection occurs in 55-32% of these patients, which can cause symptoms in these patients. Many patients with celiac disease are dissatisfied with a gluten-free diet and are interested in a non-dietary alternative treatment.  

In this study, probiotic samples of local dairy (milk, yogurt, and cheese) from Iran were collected in sterile conditions and after enzymatic extraction using a lysis buffer and a sonication method for enzyme activity of prolyl endopeptidase and aminopeptidase N were evaluated.  

The highest absorption rate for Z-Gly-Pro-4-nitroanilide substrate that performs the evaluation of prolyl endopeptidase enzyme, respectively, for strains C10-1 (L. pentosus), B6-1 (L. fermentum), C5-2 (L.paracasei), Y5 (L.paracasei) and C11-1 (L. pentosus) and in relation to Leu-p-NA which assesses aminopeptidase N The highest uptake was observed for strains K1 (L. helveticus), B8-2 (L. plantarum), Y5 (L.paracasei), P2-3 and P35 (L. plantarum), respectively. All of the above strains showed significantly different uptake than the negative control containing buffer and substrate (P <0.05). Finally, the 16s rRNA sequence of the isolated strains was registered in NCBI database.

The results of the present study showed that number of native Iranian probiotics have effective activity of prolyl endopeptidase and aminopeptidase N which can be used as a selective combination for gluten degradation and to help celiac patients.

Depression is still one of challenging, and widely encountered disorders with complex etiology. Recently the role of healthy diet and olive oil in ameliorating depression has been claimed. This study was designed to explore the effects of oleuropein on depression induced by chronic stress in mice.

To induce chronic stress (chronic restraint stress (CRS) mice immobilizated in restrainer 2 hours; for 2 weeks then an foot electric shock (2 minutes 0.5mA) were used. Mice under chronic stress were randomly divided into 5 groups; including control group (under chronic stress receiving normal saline), intervention groups (under acute stress receiving oleuropein at doses of 7.5, 15 and 30 mg/kg and positive control (under chronic stress receiving diazepam), forced swimming test (FST) and tail suspension test (TST) were recorded.

In CRS mice,at the dose of  oleuropein at 15 mg/ kg, the duration of immobility significantly reduced in tail suspension test and doses of 15 and 30 mg/ kg of oleuropein significantly decreased the immobility time in forced swimming test (P <0.05 Oleuropein also decreased the expression of 6-interleukin (6- IL) and metabotropic glutamate receptor (mGluR1).

The effect of oleuropein on depressive-like behaviors in mice under chronic stress disorder may by reducing brain inflammation and modulation of glutamate signaling

Appearance of multidrug-resistant bacteria has created significant clinical problems in treatment of infectious diseases. Sonchus oleraceus plant with many medicinal properties can be a potential source of antibacterial effects.

Aqueous and hydroalcoholic extracts of S. oleraceus were prepared by maceration  and antibacterial effect of these extracts as well as latex on Escherichia coli and Staphylococcus aureus were investigated by micro broth dilution method and MIC/ MBC according to CLSI.

Minimum lethal concentrations in latex and aqueous and hydroalcoholic extracts for E. coli respectively 7.8, 15.6 and 7.8 mg / ml and for S. aureus, respectively. 3.9, 7.8 and 62.5 mg / ml were obtained. The highest antibacterial effect was observed in plant latex on S. aureus according to the diameter of inhibition zone.

This study presents the first results of the antibacterial effects of latex and aqueous and hydroalcoholic extracts of S. oleraceus in Iran. The highest inhibitory effect was related to latex at 3.9 mg / ml on S. aureus. Further studies can help us understand the antimicrobial potential of this plant.
Keywords: Sonchus oleraceus, Latex, Aqueous extract, Hydroalcoholic extract, S. aureus, E. coli

Delivery is a painful event, and the management of labor pain is of utmost importance. Therefore, the aim of this study was to determine the effectiveness of dialectical behavior therapy techniques training combined with lavender aromatherapy on fear of childbirth and pain intensity in nulliparous women with insecure attachment to spouse.

This clinical trial study was performed in 1399 on 60 pregnant women in Birjand in the third trimester of pregnancy. Insecure attachment pregnant mothers were selected by purposive sampling method and randomly divided between three intervention groups 1 (Dialectical behavior therapy techniques training and aromatherapy), intervention group 2 aromatherapy with lavender and control group (aromatherapy with water). In order to collect data, demographic questionnaires, attachment to spouse, fear of childbirth and McGill pain were used. Data were analyzed in SPSS statistical software version 25.

intervention groups 1 (Dialectical behavior therapy techniques training and aromatherapy) In comparison with aromatherapy with lavender and control group showed significant effect on reducing fear of childbirth and Intensity of labor pain (P <0.01).   

Dialectical behavioral therapy techniques combined with aromatherapy as an effective intervention to reduce fear of childbirth and pain intensity can be use in the health centers in pregnant women with insecure attachment to the husband.